Detalhe da pesquisa
1.
The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches.
Annu Rev Biochem
; 89: 667-693, 2020 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32169021
2.
Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness.
Cell
; 183(2): 335-346.e13, 2020 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33035452
3.
Homologous mutations in human ß, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation.
Proc Natl Acad Sci U S A
; 121(9): e2315472121, 2024 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38377203
4.
Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration.
Proc Natl Acad Sci U S A
; 121(19): e2318413121, 2024 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38683993
5.
Hypertrophic cardiomyopathy ß-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state.
Proc Natl Acad Sci U S A
; 118(24)2021 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34117120
6.
Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy.
Circulation
; 144(21): 1714-1731, 2021 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34672721
7.
Deciphering the super relaxed state of human ß-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers.
Proc Natl Acad Sci U S A
; 115(35): E8143-E8152, 2018 08 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30104387
8.
Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties.
J Biol Chem
; 294(46): 17451-17462, 2019 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31582565
9.
Dilated cardiomyopathy myosin mutants have reduced force-generating capacity.
J Biol Chem
; 293(23): 9017-9029, 2018 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29666183
10.
Multidimensional structure-function relationships in human ß-cardiac myosin from population-scale genetic variation.
Proc Natl Acad Sci U S A
; 113(24): 6701-6, 2016 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27247418
11.
Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human ß-cardiac myosin.
J Exp Biol
; 219(Pt 2): 161-7, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26792326
12.
Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin.
BMC Med Genet
; 16: 97, 2015 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-26498512
13.
Motility Assay to Probe the Calcium Sensitivity of Myosin and Regulated Thin Filaments.
Methods Mol Biol
; 2735: 169-189, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38038849
14.
Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human beta-cardiac myosin allosterically.
bioRxiv
; 2024 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38464145
15.
Homologous mutations in ß , embryonic, and perinatal muscle myosins have divergent effects on molecular power generation.
bioRxiv
; 2023 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37425764
16.
Cryo-EM structure of the folded-back state of human ß-cardiac myosin.
bioRxiv
; 2023 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37131793
17.
Cryo-EM structure of the folded-back state of human ß-cardiac myosin.
Nat Commun
; 14(1): 3166, 2023 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37258552
18.
Hypertrophic cardiomyopathy: Mutations to mechanisms to therapies.
Front Physiol
; 13: 975076, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36225299
19.
Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human ß-cardiac myosin have divergent effects on myosin function.
Elife
; 112022 06 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35767336
20.
Nanomechanical Phenotypes in Cardiac Myosin-Binding Protein C Mutants That Cause Hypertrophic Cardiomyopathy.
ACS Nano
; 15(6): 10203-10216, 2021 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34060810